New discovery completely eradicated malaria (French)
The discovery of a new British scientists turn the balance of the war against the most deadly global disease, namely malaria.
It was announced and scientists at the Wellcome Trust Sanger in Cambridge on Wednesday on the progress of large may be more important than the news reported a month ago for the experimental vaccine created the British pharmaceutical company Glaxo Smith Kline, which showed partially successful in early clinical trials. The Scientists at the trials that the vaccine will contribute only to the reduction of malaria.
But the discovery of Cambridge scientists provides a glimmer of hope is not a huge total eradication of the disease globally. This goal is interesting and has become much closer, thanks to the discovery of the crucial element in the human red blood cells, which appears to be vital for the parasite to complete its life cycle inside the human body. In fact, were identified weakness in this deadly parasite. This means the possibility of designing a vaccine to prevent the development of the parasite within the infected person and thus protect against the disease and the mosquito vectors to him.
It is well known that malaria is one of the most deadly childhood diseases in the world. The estimated number of people who die each year are affected about one million, mostly children under five living in sub-Saharan Africa.
Dr. Julian Rainer Sanger Institute, the interaction "between the malaria parasite and red blood cells, which we found has the potential to be the basis of the vaccine could save millions of people."
The focus of the work behind the big reveal on the second phase of the life cycle of malaria in the human body, after he leaves the liver to invade red blood cells during the phase of what is known as "Aloksoma."
Institute scientists were able to identify a human protein called "Basegin" on the outer membrane of red blood cells of man who seems to be needed to open the parasite membrane and the invasion of the cell.
Dr. Renner "The malaria parasite travels between mosquitoes and humans back and forth. But the stage that cause actual symptoms of the disease is when the invading parasite of red blood cells of man. It must enter the red blood cell to divide and spread and multiply, and this is essential for the survival of the parasite. But also a potential target for attack. "
Once the scientists identified the protein main "future" on the red cell membrane devised a test to see if it is possible to prevent interaction between the malaria parasite and the cell.They succeeded by using antibodies designed to replicate the future adhesion protein on the parasite and thus prevents the parasite from the use of the key that opens the lock by the red cells.
For his part, said Professor Adrian Hill of the Jenner Institute, Oxford This is the great progress that can improve future vaccines. He added that reports positive results from tests developed in Africa, encouraging, and discover the future one can hope to give the target a much more effective solutions.